Akademik Veri Yönetim Sistemi
JOURNAL OF CONTEMPORARY MEDICINE, cilt.9, sa.3, ss.197-202, 2019 (Hakemli Dergi)
Introduction: Our aim was to compare NT-proBNP levels and cardiac functions after iron therapy in children with congenital cyanotic heart disease who had iron deficiency anemia.
Methods: We included 40 children with pre-established cyanotic
congenital heart disease and accompanying iron deficiency anemia, between the age of 6 months and 17 years, who were admitted
to the outpatient clinic of Çukurova University Faculty of Medicine,
Department of Pediatric Cardiology between September 2015
and March 2016. We recorded demographic data and performed
following investigations: complete blood count, peripheral blood
smear, reticulocyte count, measurement of serum iron levels, total
iron-binding capacity, ferritin levels, transferrin saturation and NTproBNP levels, and echocardiographic examination.
Results: There was a statistically significant increase in following
laboratory parameters after iron therapy: hemoglobin, hematocrit, MCV, MCHC, serum iron and ferritin, transferrin saturation
and oxygen saturation. During the follow-up period, RDW and NTproBNP levels were significantly decreased. In left ventricular tissue
doppler; there was a significant difference in MPI measurements
before and after treatment. There was no significant difference in
other echocardiography findings.
Discussion and Conclusion: Iron therapy has improved cardiac
functions in children with cyanotic congenital heart disease, and
NT-proBNP levels can be used to evaluate the efficacy of treatment
in the follow-up period